I have been told that it is not safe to enable 2FA and use Pass as an authenticator. For Proton account 2FA I am using not only Pass but also KeePassXC as a backup solution (for the case when Pass logout and requires 2FA code in order to login - and in such a case you can not get the 2FA code out of Pass - chicken-egg problem). Yet when using Pass desktop app, maybe logout issue is minimized (it remember my password across reboot and paid Pass is said to work offline).

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I wouldn’t … mostly because it discourages you from remembering/memorizing your password, and that’s not something you want to do.

FWIW: I think the local password manager only folks are a bit overly paranoid (and most folks I’ve met of the mindset end up using syncthing or something like that anyways which is basically just Proton Pass with extra steps … so I wouldn’t worry much about that side of it).